CycloRetin

CycloRetin, a natural peptide, is an active ingredient for mature skin that takes on the role of retinol in a formulation without its irritancy. It is obtained by extraction and fractionation from the adaptogenic plant Pseudostellaria heterophylla , known as prince's ginseng, and is standardised to the content of the cyclic peptide heterophyllin B . It is incorporated into serums, creams and emulsions intended for the face. The manufacturer developed it as a response to the long-standing problem with retinol: an effect on wrinkles and skin firmness yes, but at the cost of irritation, instability and the recommendation to use it only in the evening. According to the manufacturer's data, CycloRetin triggers similar pathways in the skin as retinol, but is suitable for both day and night care . What it brings to the skin Skin firmness – in the manufacturer's clinical study with 0.3% CycloRetin, skin firmness improved after four weeks and continued to increase after eight, comparable to 0.5% bakuchiol . Appearance of wrinkles – at 1% dosage, the manufacturer measured smoothing of wrinkles after just two weeks, with a result comparable to 0.3% retinol and a faster onset. Sagging contours – the manufacturer's study reports a reduction in skin sagging after four weeks, more pronounced than with bakuchiol. Brightening – the manufacturer's colorimetric measurement showed higher skin luminosity compared to both placebo and bakuchiol. Barrier and hydration support – in in vitro tests, the manufacturer observed increased expression of genes associated with barrier function and hydration