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Acetyl Hexapeptide-8 is a synthetic hexapeptide produced by solid-phase peptide synthesis (SPPS — solid-phase peptide synthesis). This technology enables precis... read more
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Acetyl Hexapeptide-8 is a synthetic hexapeptide produced by solid-phase peptide synthesis (SPPS — solid-phase peptide synthesis). This technology enables precise assembly of the peptide chain from individual amino acids on a solid support, thereby guaranteeing a defined sequence and high product purity. After completion of the synthesis, N-terminal acetylation is carried out, which stabilises the molecule against enzymatic degradation and improves its percutaneous penetration. The peptide is a structural mimic of the N-terminal segment of the protein SNAP-25 (synaptosomal-associated protein 25) — a key component of the SNARE complex, which controls the release of acetylcholine at the neuromuscular junction. By competitively binding to the SNAP-25 site, Acetyl Hexapeptide-8 limits formation of the SNARE complex, reduces the intensity of muscular microcontractions and decreases the formation and deepening of dynamic expression lines. SpecPed® SC-AH8 is a pre-formulated aqueous solution from the manufacturer Spec-Chem Industry Inc. (Nanjing, China) with a certified peptide concentration of ≥ 0,05 %. The carrier — a combination of Caprylyl Glycol and Ethylhexylglycerin — simultaneously provides preservative and hydrating functions, which enables direct inclusion in the formulation without further treatment.
Dosage: 0.5–3 % for everyday use; 3–10 % for intensive care.Phase: aqueous — disperses homogeneously in both cold and warm water phase.Solubility: in water.pH of solution: 5.0–7.0 (according to CoA). Maintain the formulation within this range for optimal peptide stability.It is recommended to add during the cooling phase (at a temperature below 40 °C) in order to minimise thermal degradation of the peptide bond. Compatibility:
Yes, it is the same substance. Acetyl Hexapeptide-3 is the older INCI name, which was updated in 2011 to Acetyl Hexapeptide-8 following revision of the INCI nomenclature. Argireline® is a registered trademark of the original manufacturer Lipotec (BASF). SpecPed® SC-AH8 from Spec-Chem Industry Inc. contains the same active molecule under the generic INCI name.
Yes. Caprylyl Glycol and Ethylhexylglycerin are present in the product as carrier excipients (a total of 0.5 % in the raw material). At a dosage of 1–3 % SpecPed SC-AH8 in the final formulation, their resulting concentration is too low to ensure preservation of the product. Aqueous cosmetic preparations always require their own validated preservation system.
SpecPed® SC-AH8 is a pre-formulated solution with a certified peptide concentration ≥ 0.05 %. The dosage refers to the entire solution — it allows direct, accurate measuring without the need to work with concentrated peptide powder or perform your own dilution. The manufacturer guarantees a defined active content (CoA: 0.053 % measured batch 26012601) in every batch.
The combination is common but requires attention to pH. Pure ascorbic acid (L-AA) significantly lowers the pH of the formulation (below 3.5), which is outside the recommended range for SpecPed SC-AH8 (5.0–7.0) and may destabilise the peptide. For a stable combination, give preference to more neutral vitamin C derivatives — Ascorbyl Glucoside or Sodium Ascorbyl Phosphate, where the formulation pH remains within a compatible range.
After emulsification and cooling of the emulsion below 40 °C. Peptide bonds are sensitive to hydrolysis accelerated by heat, so exposure to emulsification temperature (70–80 °C) is undesirable. In serum formulations without heating (cold water phase), it can be added directly at the beginning — in this case, thermal load is not an issue.
The requirement of 2–8 °C applies to long-term storage (months) in order to maintain the certified peptide content ≥ 0.05 %. For routine work, a dry, cool and light-protected place is sufficient. It is reasonable to return the opened stock to the refrigerator after each use and to use it up within an appropriate timeframe.
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