CycloRetin, Natural Peptide, 10 ml

CycloRetin is a natural cyclic peptide titrated in an extract from the root of Pseudostellaria heterophylla (the so‑called “prince ginseng”), designed as a gentle alternative to retinol with high stability and efficacy even at low dosages. It activates key targets of the retinoid pathway and supports the synthesis of collagen and elastin, thereby improving skin firmness and contours without the usual irritation associated with retinol. The water‑soluble form facilitates use in the aqueous phase of serums and creams, including daytime formulations.

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Key benefits

• Wrinkle reduction already after 14 days (D14 −5.1 %; D28 −7.1 %), with an effect comparable to retinol.
• Increased skin firmness (+12.6 % after 28 days; +19 % after 56 days).
• Anti‑gravity effect – visible facial contour lifting, reduced sagging (D28 −10.7 % vs. placebo; better than bakuchiol).
• Brightening of the complexion (L* parameter, ~9.5× better than placebo).
• Strengthening of the skin barrier and hydration
• Collagen stimulation (Collagen I +133 %, SPARC +99 %); 3× more effective than bakuchiol in pro‑collagen I.
• Gentle on sensitive skin – patch tests: at 0.3–1 % with no irritation; retinol 0.1–0.3 % mildly irritating.

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Suitable for products such as

• anti‑age serums and ampoules (day & night)
• firming creams (intended for facial contours)
• plumping/firming gels and treatments
• night‑time regenerating creams and eye products

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Use in formulation

• Solubility: soluble in water; compatible with alcohol and glycols (up to 100 %).
• Recommended dosage: 0.3–2.5 % (clinical protocols: 0.3 % and 1 %).
• Processing phase: add to the aqueous phase, ideally after cooling and after dispersing the other water‑soluble actives.
• Max. processing temperature: add below 50 °C; protect from direct light. Tolerated pH ~3–8.

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CycloRetin is a natural cyclic peptide – a gentle alternative to retinol – that quickly softens wrinkles, firms the skin, defines contours and strengthens the skin barrier, while being water‑soluble and easy to use in the aqueous phase of serums and creams.

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More detailed information on product quality can be found in the certificate of analysis, which we update with each new batch.

All supplied raw materials are of cosmetic grade, not suitable for internal use.

Use appropriate protective equipment when handling.